BGI-Newsletter
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| BGI-Online |
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BGI has developed a powerful and highly secure cloud-based genomic computing platform, known as
BGI Online, aims to provide easier and more effective solutions for a wide range of problems faced by bioinformaticians. With more robust software, a high level of data security, and well-designed data logistics, BGI Online liberates researchers from the constraints of limited storage space, high labor costs, data delivery, and endless command lines in data analysis. |
NIFTY |
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NIFTYTM(Non-Invasive Fetal TrisomY test) is a safe, simple, non-invasive
prenatal test ( an NIPT), which offers screening for certain genetic conditions from as early as week 10 of pregnancy.Using the latest genetic sequencing technology, NIFTY™ has over
>99% accuracy for the three most common trisomy conditions present
at birth, which are Down Syndrome, Edwards Syndrome and Patau
Syndrome. To find out more about the test, please click on the link
below. |
Digital Breeding |
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BGI Digital Breeding is based on BGI Biomarker System, a NGS/array-based molecular marker development system. We provide DNA fingerprinting, genetic purity, germplasm resources screening, gene mapping, MAS, GS, as well as cross combination recommendation, simulation breeding database services, help realize the computer simulation of digital breeding process, BGI aims to construct the environment, phenotype, and genotype integrated database of important economic species accelerating breeding process. |
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| Genomic signatures of evolutionary transitions from solitary to group living |
| Science DOI: 10.1126/science.aaa4788/Plos one. DOI: 10.1371 |
| The evolution of eusociality is one of the major transitions in evolution, but the underlying genomic changes are unknown. We compared the genomes of ten bee species that vary in social complexity, representing multiple independent transitions in social evolution, and report three major findings. First, many important genes show evidence of neutral evolution as a consequence of relaxed selection with increasing social complexity. Second, there is no single road map to eusociality; independent evolutionary transitions in sociality have independent genetic underpinnings. Third, though clearly independent in detail, these transitions do have similar general features, including an increase in constrained protein evolution accompanied by increases in the potential for gene regulation and decreases in diversity and abundance of transposable elements. Eusociality may arise through different mechanisms each time, but would likely always involve an increase in the complexity of gene networks. |
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| An Integrated Tool to Study MHC Region: Accurate SNV Detection and HLA Genes Typing in Human MHC Region Using Targeted High-Throughput Sequencing |
| Plos one. DOI: 10.1371/journal.pone.0069388. |
| The study presented a method for the accurate detection of minor variants and HLA types in the human MHC region using high-throughput, high-coverage sequencing of target regions. A probe set was designed as a template based on eight annotated human MHC haplotypes and it encompasses 5 megabases (Mb) of the extended MHC region. The results showed that >97% of the overall MHC region and >99% of the gene coding regions were covered with sufficient depth and good evenness. Moreover, 98% of genotypes called by this capture sequencing were proved to be consistent with established HapMap genotypes. In addition, we have concurrently developed a one-step pipeline (the left figure) for calling any HLA type referenced in the IMGT/HLA database from this target capture sequencing data has been developed, which shows over 96% typing accuracy when deployed at 4 digital resolution. |
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